SNP And Cancer

A single-nucleotide variant (SNV) is a variation in a single nucleotide without any limitations of frequency. SNV differs from SNP because when an SNV is detected in a sample from one organism of a species the SNV could potentially be a SNP but this cannot be determined from only one organism. SNP however means the nucleotide varies in a species' population of organisms. SNVs may arise in somatic cells. A somatic single-nucleotide variation (e.g., caused by cancer) may also be called a single-nucleotide alteration. SNVs also commonly arise in molecular diagnostics. For example when designing PCR primers to detect viruses, the viral RNA or DNA in a single patient sample may contain SNVs.